|
Symbol Name ID |
Pla2g6
phospholipase A2, group VI MGI:1859152 |
| Darker colors indicate more annotations |
| Human Phenotypes | Drooling |
Hyposmia |
Eyelid apraxia |
Torticollis |
Ankle clonus |
Dysphagia |
Abnormality of visual evoked potentials |
Spasticity |
Spastic tetraplegia |
Gliosis |
Cerebral atrophy |
Frontotemporal cerebral atrophy |
Lewy bodies |
Neurofibrillary tangles |
Cerebellar atrophy |
Global brain atrophy |
Iron accumulation in brain |
Abnormal pyramidal tract morphology |
Neurodegeneration |
Neuronal loss in central nervous system |
Ataxia |
Dysdiadochokinesis |
Dysmetria |
Gait ataxia |
Clumsiness |
Bradykinesia |
Parkinsonism |
Chorea |
Eyelid myoclonus |
Tremor |
Intention tremor |
Upper limb postural tremor |
Resting tremor |
Pill-rolling tremor |
Hand tremor |
Abnormal pyramidal sign |
Babinski sign |
Hemiparesis |
Decreased nerve conduction velocity |
Delayed speech and language development |
Dysarthria |
Mutism |
Depression |
Emotional lability |
Anxiety |
Panic attack |
Hallucinations |
Apathy |
Reduced social reciprocity |
Personality changes |
Aggressive behavior |
Hyperactivity |
Impulsivity |
Agitation |
Restless legs |
Cognitive impairment |
Mental deterioration |
Dementia |
Frontal lobe dementia |
Frontotemporal dementia |
Short attention span |
Intellectual disability |
Insomnia |
Hyperreflexia |
Brisk reflexes |
Areflexia |
Dyskinesia |
Dystonia |
Axial dystonia |
Craniofacial dystonia |
Limb dystonia |
Gait imbalance |
Loss of ambulation |
Unsteady gait |
Postural instability |
Bulbar signs |
Developmental regression |
Global developmental delay |
Motor delay |
Seizure |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with PLA2G6 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| dystonia 12 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| neurodegeneration with brain iron accumulation 2a | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| neurodegeneration with brain iron accumulation 2b | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Parkinson's disease | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Parkinson's disease 14 |
| Mouse Phenotypes | abnormal nervous system morphology |
abnormal brain morphology |
abnormal brain white matter morphology |
abnormal brainstem morphology |
abnormal substantia nigra pars compacta morphology |
abnormal axon morphology |
abnormal myelin sheath morphology |
abnormal synaptic bouton morphology |
neuron degeneration |
abnormal sciatic nerve morphology |
abnormal spinal cord morphology |
abnormal spinal cord grey matter morphology |
abnormal spinal cord ventral horn morphology |
Lewy bodies |
neurodegeneration |
axon degeneration |
axonal dystrophy |
axonal spheroids |
abnormal astrocyte physiology |
|
| Availability | Mouse Genotype | |||||||||||||||||||
| Pla2g6m1J/Pla2g6m1J | ||||||||||||||||||||
| Pla2g6m1Sein/Pla2g6m1Sein | ||||||||||||||||||||
| Pla2g6tm1.1Hlw/Pla2g6tm1.1Hlw | ||||||||||||||||||||
| Pla2g6tm1Tsu/Pla2g6tm1Tsu | ||||||||||||||||||||
| Pla2g6tm1Turk/Pla2g6tm1Turk | ||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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